Molecular classification of primary melanomas by their risk of recurrenceOur lab is searching for molecular alterations in tumors that can be robustly measured at diagnosis and could be useful prognostic markers, as well as reveal novel insights into melanoma biology.
Melanoma metastasis: Beyond the coding genomeGiven that malignant cells with the same genetic features can elicit diverse epigenetic programs to adapt to different microenvironments, we posit that epigenetic regulators might be critical drivers of metastasis.
Molecular basis of melanoma brain metastasisOur lab is employing novel in vitro and in vivo models to dissect the molecular basis of brain metastasis, a devastating consequence of melanoma progression which leaves patients with few clinical options.
Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
Kleffman K, Levinson G, Rose IVL, Blumenberg LM, Shadaloey SAA, Dhabaria A, Wong E, Galan-Echevarria F, Karz A, Argibay D, Von Itter R, Floristan A, Baptiste G, Eskow NM, Tranos JA, Chen J, Vega Y Saenz de Miera EC, Call M, Rogers R, Jour G, Wadghiri YZ, Osman I, Li YM, Mathews P, DeMattos R, Ueberheide B, Ruggles KV, Liddelow SA, Schneider RJ, Hernando E.Cancer Discov. 2022 Feb 24:candisc.1006.2021. doi: 10.1158/2159-8290.CD-21-1006. Online ahead of print.