Molecular classification of primary melanomas by their risk of recurrenceOur lab is searching for molecular alterations in tumors that can be robustly measured at diagnosis and could be useful prognostic markers, as well as reveal novel insights into melanoma biology.
Melanoma metastasis: Beyond the coding genomeGiven that malignant cells with the same genetic features can elicit diverse epigenetic programs to adapt to different microenvironments, we posit that epigenetic regulators might be critical drivers of metastasis.
Molecular basis of melanoma brain metastasisOur lab is employing novel in vitro and in vivo models to dissect the molecular basis of brain metastasis, a devastating consequence of melanoma progression which leaves patients with few clinical options.
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
Veronica Davalos, Claudia D. Lovell, Richard Von Itter, Igor Dolgalev, Praveen Agrawal, Gillian Baptiste, David J. Kahler, Elena Sokolova, Sebastian Moran, Laia Piqué, Eleazar Vega-Saenz de Miera, Barbara Fontanals-Cirera, Alcida Karz, Aristotelis Tsirigos, Chi Yun, Farbod Darvishian, Heather C. Etchevers, Iman Osman, Manel Esteller, Markus Schober & Eva Hernando. Nature Communications volume 14, Article number: 1867 (2023)