Molecular classification of primary melanomas by their risk of recurrenceOur lab is searching for molecular alterations in tumors that can be robustly measured at diagnosis and could be useful prognostic markers, as well as reveal novel insights into melanoma biology.
Melanoma metastasis: Beyond the coding genomeGiven that malignant cells with the same genetic features can elicit diverse epigenetic programs to adapt to different microenvironments, we posit that epigenetic regulators might be critical drivers of metastasis.
Molecular basis of melanoma brain metastasisOur lab is employing novel in vitro and in vivo models to dissect the molecular basis of brain metastasis, a devastating consequence of melanoma progression which leaves patients with few clinical options.
Human genes differ by their UV sensitivity estimated through analysis of UV-induced silent mutations in melanoma
Gorlov, Ivan P; Amos, Christopher I; Tsavachidis, Spiridon; Begg, Colin; Hernando, Eva; Cheng, Chao; Shen, Ronglai; Orlow, Irene; Luo, Li; Ernstoff, Marc S; Parker, Joel; Thomas, Nancy E; Gorlova, Olga Y; Berwick, Marianne. Hum Mutat. 2020 Jul 9. doi: 10.1002/humu.24078. Online ahead of print.