Publications
Harnessing BET inhibitor sensitivity reveals AMIGO2 as a melanoma survival gene
Fontanals-Cirera, B., Hasson, D., Vardabasso, C., Di Micco, R., Agrawal, P., Chowdhury, A., Gantz, M., de Pablos-Aragoneses, A., Morgenstern, A., Wu, P., Filipescu, D., Valle-Garcia, D., Darvishian, F., Roe, J. S., Davies, M. A., Vakoc, C. R., Hernando, E., & Bernstein, E. (2017). Molecular cell, 68(4), 731–744.e9.
PMID: 29149598
A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis
Agrawal, P., Fontanals-Cirera, B., Sokolova, E., Jacob, S., Vaiana, C. A., Argibay, D., Davalos, V., McDermott, M., Nayak, S., Darvishian, F., Castillo, M., Ueberheide, B., Osman, I., Fenyö, D., Mahal, L. K., & Hernando, E. (2017). Cancer cell, 31(6), 804–819.e7.
PMID: 28609658
Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions
Segura, M. F., Jubierre, L., Li, S., Soriano, A., Koetz, L., Gaziel-Sovran, A., Masanas, M., Kleffman, K., Dankert, J. F., Walsh, M. J., & Hernando, E. (2017). Oncotarget, 8(16), 26298–26311.
PMID: 28412746
TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy
Martinez-Ruiz, H., Illa-Bochaca, I., Omene, C., Hanniford, D., Liu, Q., Hernando, E., & Barcellos-Hoff, M. H. (2016). Science signaling, 9(457), ra118.
PMID: 27923913
MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway
Koetz-Ploch, L., Hanniford, D., Dolgalev, I., Sokolova, E., Zhong, J., Díaz-Martínez, M., Bernstein, E., Darvishian, F., Flaherty, K. T., Chapman, P. B., Tawbi, H., & Hernando, E. (2017). Pigment cell & melanoma research, 30(3), 328–338.
PMID: 28140520
BET and BRAF inhibitors act synergistically against BRAF mutant melanoma
Paoluzzi, L., Hanniford, D., Sokolova, E., Osman, I., Darvishian, F., Wang, J., Bradner, J. E., & Hernando, E. (2016). Cancer medicine, 5(6), 1183–1193.
PMID: 27169980
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150
Barbáchano, A., Fernández-Barral, A., Pereira, F., Segura, M. F., Ordóñez-Morán, P., Carrillo-de Santa Pau, E., González-Sancho, J. M., Hanniford, D., Martínez, N., Costales-Carrera, A., Real, F. X., Pálmer, H. G., Rojas, J. M., Hernando, E., & Muñoz, A. (2016). Oncogene, 35(23), 2991–3003.
PMID: 26455323
Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma
Vardabasso, C., Gaspar-Maia, A., Hasson, D., Pünzeler, S., Valle-Garcia, D., Straub, T., Keilhauer, E. C., Strub, T., Dong, J., Panda, T., Chung, C. Y., Yao, J. L., Singh, R., Segura, M. F., Fontanals-Cirera, B., Verma, A., Mann, M., Hernando, E., Hake, S. B., & Bernstein, E. (2015). Molecular cell, 59(1), 75–88.
PMID: 26051178
A 4-microRNA signature detected in primary melanoma tissue predicts development of brain metastasis
Hanniford, D., Zhong, J., Koetz, L., Gaziel-Sovran, A., Lackaye, D. J., Shang, S., Pavlick, A., Shapiro, R., Berman, R., Darvishian, F., Shao, Y., Osman, I., & Hernando, E. (2015). Clinical cancer research: an official journal of the American Association for Cancer Research, 21(21), 4903–4912.
PMID: 26089374
RSK1 activation promotes invasion in nodular melanoma
Salhi, A., Farhadian, J. A., Giles, K. M., Vega-Saenz de Miera, E., Silva, I. P., Bourque, C., Yeh, K., Chhangawala, S., Wang, J., Ye, F., Zhang, D. Y., Hernando-Monge, E., Houvras, Y., & Osman, I. (2015). The American journal of pathology, 185(3), 704–716.
PMID: 25779178
FBXW7 modulates cellular stress response and metastatic potential through post-translational modification of HSF1
Kourtis, N.#, Moubarak, R. S.#, Aranda-Orgilles, B., Lui, K., Aydin, I. T., Trimarchi, T., Darvishian, F., Salvaggio, C., Zhong, J., Bhatt, K., Chen, E. I., Celebi, J. T., Lazaris, C., Tsirigos, A., Osman, I., Hernando, E., & Aifantis, I. (2015). Nature cell biology, 17(3), 322–332.
PMID: 25720964